Triclosan과 Ursodesoxycholic acid배합세치제가 치은염완화 및 치식형성억제에 미치는 영향에 과한 연구
Effect of dentifrice containing Triclosan and Ursodesoxycholic acid on gingivitis and calculus formation
마득상, 박덕영, 이승우, 김종배, 백대일, 문혁수, 이진환, 김문무,
소속 상세정보
마득상 ( Ma Deuk-Sang ) - 강릉대학교 치과대학 예방치학교실
박덕영 ( Park Deok-Young ) - 강릉대학교 치과대학 예방치학교실
이승우 ( Lee Seung-Woo ) - 강릉대학교 치과대학 예방치학교실
김종배 ( Kim Johng-Bai ) - 서울대학교 치과대학 예방치학교실 및 국민구강보건연구소
백대일 ( Paik Dai-Il ) - 서울대학교 치과대학 예방치학교실 및 국민구강보건연구소
문혁수 ( Moon Hyuck-Soo ) - 서울대학교 치과대학 예방치학교실 및 국민구강보건연구소
이진환 ( Lee Jin-Wan ) - LG 생활건강연구원 생활과학연구소 구강제품연구팀
김문무 ( Kim Moon-Moo ) - LG 생활건강연구원 생활과학연구소 구강제품연구팀
KMID : 0355420010250020199
Abstract
The aim of this study was to examine the effect of dentifrice containing 0.3% triclosan and 0.02% ursodesoxycholic acid(UDCA) on the reduction effect of gingivitis and calculus formation.
The study participants was composed of 70 women for examining gingivitis and 40 men and women for examining calculus formation.All participants were aged 20-24 years. Participants and investigators were blinded to group assignment and followed for 12 weeks on gingivitis and for 4 weeks on calculus formation.
We also investigated adsorbed/remaining concentration of triclosan of dentifrice dentifrice containing 0.3% triclosan and 0.02% UDCA on hydroxyapatite disk by laboratory study.
Obtained results were as follows:
1. Adsorbed concentration and remaining concentration of triclosan in dentifrice on hyroxyapatite disk was increased about 70% and 96% respectively by addition of UDCA(P (0.01).
2. After 12 weeks of use, gingivitis index was significantly reduced(P (0.05) among participants using dentifrice containing 0.3% triclosan and 0.02% UDCA while difference of gingivitis index of control group was not significant(P)0.05).
3. After 4 weeks of use, claculus formation was significantly reduced among participants using dentifrice containing 0.3% triclosan and 0.02% UDCA compared to the control group(P (0.05).
키워드
세치제;치은염;치석
Ursodesoxycholic acid;Triclosan
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